Histology Review Supplement

Histology Review Supplement The slides in this section are designed to provide a basic histology review related to topics introduced in the PhysioEx lab simulations and in your anatomy and physiology textbook. From the PhysioEx main menu, select Histology Tutorial. The opening screen should appear after a few seconds. The Sort by menu is located at the top left. Click on the white drop-down menu and select â€Å"Histology Review† from the list. You will note that the slides in the histology module are grouped in the following folders: Skeletal muscle slides Nervous tissue slides Endocrine tissue slides Cardiovascular tissue slides Respiratory tissue slides Digestive tissue slides Renal tissue slides Select the group of slides you wish to view, and then refer to the relevant worksheet in this section for a step-by-step tutorial. For example, if you would like to review the skeletal muscle slides, click on the Skeletal muscle slides folder, and then turn to the next page of this lab manual for the worksheet entitled Skeletal Muscle Tissue Review to begin your review. You will have the option of viewing slides with or without labels by clicking the On/Off buttons at the bottom left of the viewer. Since the slides in this module have been selected for their relevance to topics covered in the PhysioEx lab simulation, it is recommended that you complete the worksheets along with a related PhysioEx lab. For example, you might complete the Skeletal Muscle Tissue worksheet right before or after your instructor assigns you Exercise 2, the PhysioEx lab simulation on Skeletal Muscle Physiology. For additional histology review, turn to page 121. 23 Skeletal Muscle Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Skeletal muscle slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. Click slide 1. Skeletal muscle is composed of extremely large, cylindrical multinucleated cells called myofibers. The nuc lei of the skeletal muscle cell (myonuclei) are located peripherally just subjacent to the muscle cell plasmalemma (sarcolemma). The interior of the cell is literally filled with an assembly of contractile proteins (myofilaments) arranged in a specific overlapping pattern oriented parallel to the long axis of the cell. Click slides 2, 3. Sarcomeres are the functional units of skeletal muscle. The organization of contractile proteins into a regular end-to-end repeating pattern of sarcomeres along the length of each cell accounts for the striated, or striped, appearance of skeletal muscle in longitudinal section. Click slide 4. The smooth endoplasmic reticulum (sarcoplasmic reticulum), modified into an extensive network of membranous channels that store, release, and take up the calcium necessary for contraction, also functions to further organize the myofilaments inside the cell into cylindrical bundles called myofibrils. The stippled appearance of the cytoplasm in cells cut in cross section represents the internal organization of myofilaments bundled into myofibrils by the membranous sarcoplasmic reticulum. What is the functional unit of contraction in skeletal muscle? Click slide 5. The neural stimulus for contraction arises from the axon of a motor neuron whose axon terminal comes into close apposition to the muscle cell sarcolemma. Would you characterize skeletal muscle as voluntary or involuntary? Name the site of close juxtaposition of an axon terminal with the muscle cell plasmalemma. Skeletal muscle also has an extensive connective tissue component that, in addition to conducting blood vessels and nerves, becomes continuous with the connective tissue of its tendon. The tendon in turn is directly continuous with the connective tissue covering (the periosteum) of the adjacent bone. This connective tissue continuity from muscle to tendon to bone is the basis for movement of the musculoskeletal system. What is the name of the loose areolar connective tissue covering of an individual muscle fiber? endomysium The perimysium is a collagenous connective tissue layer that groups several muscle fibers together into bundles called fascicles . the sacromeres What are the two principal contractile proteins that compose the functional unit of contraction? Which connective tissue layer surrounds the entire muscle and merges with the connective tissue of tendons and aponeuroses? epimysium actin and myosin What is the specific relationship of the functional unit of contraction to the striated appearance of a skeletal muscle fiber? the repeating pattern of the sacromeres organized end to end 124 Histology Review Supplement Nervous Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Nervous tissue slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. Nervous tissue is composed of nerve cells (neurons) and a variety of support cells. Click slide 1. Each nerve cell consists of a cell body (perikaryon) and one or more cellular processes (axon and dendrites) extending from it. The cell body contains the nucleus, which is typically pale-staining and round or spherical in shape, and the usual assortment of cytoplasmic organelles. Characteristically, the nucleus features a prominent nucleolus often described as resembling the upil of a bird’s eye (â€Å"bird’s eye,† or â€Å"owl’s eye,† nucleolus). Click slide 2. The cytoplasm of the cell body is most often granular in appearance due to the presence of darkly stained clumps of ribosomes and rough endoplasmic reticulum (Nissl bodies/ Nissl substance). Generally, a single axon arises from the cell body at a pale-staining region (axon hillock), devoid of Nissl b odies. The location and number of dendrites arising from the cell body varies greatly. Axons and dendrites are grouped together in the peripheral nervous system (PNS) to form peripheral nerves. What is the primary unit of function in nervous tissue? Click slide 5. Because Schwann cells are aligned in series and myelinate only a small segment of a single axon, small gaps occur between the myelin sheaths of adjacent contiguous Schwann cells. The gaps, called nodes of Ranvier, together with the insulating properties of myelin, enhance the speed of conduction of electrical impulses along the length of the axon. Different support cells and myelinating cells are present in the central nervous system (CNS). What is the general name for all support cells within the CNS? neuroglial cells Name the specific myelinating cell of the CNS. Oligodendrocyte In the PNS, connective tissue also plays a role in providing support and organization. In fact, the composition and organization of the connective tissue investments of peripheral nerves are similar to those of skeletal muscle. Click slide 3. Each individual axon or dendrite is surrounded by a thin and delicate layer of loose connective tissue called the endoneurium (not shown. ) The perineurium, a slightly thicker layer of loose connective tissue, groups many axons and dendrites together into bundles (fascicles). The outermost epineurium surrounds the entire nerve with a thick layer of dense irregular connective tissue, often infiltrated with adipose tissue, that conveys blood and lymphatic vessels to the nerve. There is no connective tissue component within the nervous tissue of the CNS. What is the relationship of the endoneurium to the myelin sheath? neuron Name the pale-staining region of the cell body from which the axon arises. nucleus The support cells of the nervous system perform extremely important functions including support, protection, insulation, and maintenance and regulation of the microenvironment that surrounds the nerve cells. Click slides 3, 4. In the PNS, support cells surround cell bodies (satellite cells) and individual axons and dendrites (Schwann cells). Schwann cells, in particular, are responsible for wrapping their cell membrane jelly-roll style around axons and dendrites to form an insulating sleeve called the myelin sheath. enclosed and protects Histology Review Supplement 125 Endocrine Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Endocrine tissue slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. antrum, except for a thin rim of granulosa cells (corona radiata) that encircles the oocyte and a pedestal of granulosa cells (cumulus oophorus) that attaches the oocyte to the inner wall of the antrum. Which cells of the ovarian follicle secrete estrogen? Thyroid Gland The thyroid gland regulates metabolism by regulating the secretion of the hormones T3 (triiodothyronine) and T4 (thyroxine) into the blood. Click slide 1. The gland is composed of fluid-filled (colloid) spheres, called follicles, formed by a simple epithelium that can be squamous to columnar depending upon the gland’s activity. The colloid stored in the follicles is primarily composed of a glycoprotein (thyroglobulin) that is synthesized and secreted by the follicular cells. Under the influence of the pituitary gland, the follicular cells take up the colloid, convert it into T3 and T4, and secrete the T3 and T4 into an extensive capillary network. A second population of cells, parafollicular (C) cells (not shown), may be found scattered through the follicular epithelium but often are present in the connective tissue between follicles. The pale-staining parafollicular cells secrete the protein hormone calcitonin. Why is the thyroid gland considered to be an endocrine organ? Uterus Click slides 4, 5, 6. The uterus is a hollow muscular organ with three major layers: the endometrium, myometrium, and either an adventitia or a serosa. The middle, myometrial layer of the uterine wall is composed of several layers of smooth muscle oriented in different planes. Click slide 6. The innermost (nearest the lumen) endometrial layer is further divided functionally into a superficial functional layer (stratum functionalis) and a deep basal layer (stratum basalis). Click slide 4. A simple columnar epithelium with both ciliated and nonciliated cells lines the surface of the endometrium. The endometrial connective tissue features an abundance of tubular endometrial glands that extend from the base to the surface of the layer. During the proliferative phase of the menstrual cycle, shown here, the endometrium becomes thicker as the glands and blood vessels proliferate. Click slide 5. In the secretory phase, the endometrium and its glands and blood vessels are fully expanded. Click slide 6. In the menstrual phase, the glands and blood vessels degenerate as the functional layer of the endometrium sloughs away. The deep basal layer (stratum basalis) is not sloughed and will regenerate the endometrium during the next proliferative phase. Which layer of the endometrium is shed during the menstrual phase of the menstrual cycle? it secrets a horomone What hormone secreted by the pituitary gland controls the synthesis and secretion of T3 and T4? TSH – thyroid stimulating hormone What is the function of calcitonin? causes CA to be released into blood Ovary The ovary is an organ that serves both an exocrine function in producing eggs (ova) and an endocrine function in secreting the hormones estrogen and progesterone. Click slide 2. Grossly, the ovary is divided into a peripherally located cortex in which the oocytes (precursors to the ovulated egg) develop and a central medulla in which connective tissue surrounds blood vessels, lymphatic vessels and nerves. The oocytes, together with supporting cells (granulosa cells), form the ovarian follicles seen in the cortex at various stages of development. Click slide 3. As an individual oocyte grows, granulosa cells proliferate from a single layer of cuboidal cells that surround the oocyte to a multicellular layer that defines a fluid-filled spherical follicle. In a mature follicle (Graafian follicle), the granulosa cells are displaced to the periphery of the fluid-filled 126 Histology Review Supplement endometrium What is the function of the deep basal layer (stratum basalis) of the endometrium? regenerate new superficial layer What composes a serosa? perimetrium How does the serosa of the uterus, where present, differ from visceral peritoneum? location Pancreas The pancreas is both an endocrine and an exocrine gland. Click slide 7. The exocrine portion is characterized by glandular secretory units (acini) formed by a simple epithelium of triangular or pyramidal cells that encircle a small central lumen. The central lumen is the direct connection to the duct system that conveys the exocrine secretions out of the gland. Scattered among the exocrine secretory units are the pale-staining clusters of cells that compose the endocrine portion of the gland. The cells that form these clusters, called pancreatic islet cells (islets of Langerhans), secrete a number of hormones, including insulin and glucagon. Do the pancreatic islets secrete their hormones into the same duct system used by the exocrine secretory cells? no, but directly into blood stream Histology Review Supplement 127 Cardiovascular Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Cardiovascular Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. Which component of the intercalated disc is a junction that provides the intercellular communication required for the myocardium to perform as a functional syncytium? gap juntions Blood Vessels Blood vessels form a system of conduits through which lifesustaining blood is conveyed from the heart to all parts of the body and back to the heart again. Click slide 3. Generally, the wall of every vessel is described as being composed of three layers, or tunics. The tunica intima, or tunica interna, a simple squamous endothelium and a small amount of subjacent loose connective tissue, is the innermost layer adjacent to the vessel lumen. Smooth muscle and elastin are the predominant constituents of the middle tunica media, and the outermost tunica adventitia, or tunica externa, is a connective tissue layer of variable thickness that provides support and transmits smaller blood and lymphatic vessels and nerves. The thickness of each tunic varies widely with location and function of the vessel. Arteries, subjected to considerable pressure fluctuations, have thicker walls overall, with the tunica media being thicker than the tunica adventitia. Veins, in contrast, are subjected to much lower pressures and have thinner walls overall, with the tunica adventitia often outsizing the tunica media. Because thin-walled veins conduct blood back to the heart against gravity, valves (not present in arteries) also are present at intervals to prevent backflow. In capillaries, where exchange occurs between the blood and tissues, the tunica intima alone composes the vessel wall. The tunica media of the aorta would have a much greater proportion of what type of tissue than a small artery? Heart The heart is a four-chambered muscular pump. Although its wall can be divided into three distinct histological layers (endocardium, myocardium, and epicardium), the cardiac muscle of the myocardium composes the bulk of the heart wall. Click slide 1. Contractile cardiac muscle cells (myocytes, myofibers) have the same striated appearance as skeletal muscle, but are branched rather than cylindrical in shape and have one (occasionally two) nucleus (myonucleus) rather than many. The cytoplasmic striations represent the same organization of myofilaments (sarcomeres) and alignment of sarcomeres as in skeletal muscle, and the mechanism of contraction is the same. The intercalated disc, however, is a feature unique to cardiac muscle. The densely stained structure is a complex of intercellular junctions (desmosomes, gap junctions, fasciae adherens) that structurally and functionally link cardiac muscle cells end to end. A second population of cells in the myocardium composes the noncontractile intrinsic conduction system (nodal system). Although cardiac muscle is autorhythmic, meaning it has the ability to contract involuntarily in the absence of extrinsic innervation provided by the nervous system, it is the intrinsic conduction system that prescribes the rate and orderly sequence of contraction. Extrinsic innervation only modulates the inherent activity. Click slide 2. Of the various components of the noncontractile intrinsic conduction system, Purkinje fibers are the most readily observed histologically. They are particularly abundant in the ventricular myocardium and are recognized by their very pale-staining cytoplasm and larger diameter. The connective tissue component of cardiac muscle is relatively sparse and lacks the organization present in skeletal muscle. Which component of the intercalated disc is a strong intercellular junction that functions to keep cells from being pulled apart during contraction? lastic fiber In general, which vessel would have a larger lumen, an artery or its corresponding vein? vein Why would the tunica media and tunica adventitia not be present in a capillary? to allow material exchange between blood and tissue desmosomes What is a functional syncytium? Because the cardiac muscle cells are mechanically, chemically, and electrically connecte d to one another, the entire tissue resembles a single, enormous muscle cell. 128 Histology Review Supplement Respiratory Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Respiratory Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. The respiratory system serves both to conduct oxygenated air deep into the lungs and to exchange oxygen and carbon dioxide between the air and the blood. The trachea, bronchi, and bronchioles are the part of the system of airways that conduct air into the lungs. Click slide 2. The trachea and bronchi are similar in morphology. Their lumens are lined by pseudostratified columnar ciliated epithelium with goblet cells (respiratory epithelium), underlain by a connective tissue lamina propria and a deeper connective tissue submucosa with coiled sero-mucous glands that open onto the surface lining of the airway lumen. Click slide 1. Deep to the submucosa are the hyaline cartilage rings that add structure to the wall of the airway and prevent its collapse. Peripheral to the cartilage is a connective tissue adventitia. The sero-mucous glands are also visible in this slide. Click slide 3. The bronchioles, in contrast, are much smaller in diameter with a continuous layer of smooth muscle in place of the cartilaginous reinforcements. A gradual decrease in the height of the epithelium to simple columnar also occurs as the bronchioles decrease in diameter. Distally the bronchioles give way to the respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli in which gas exchange occurs. In the respiratory bronchiole, the epithelium becomes simple cuboidal and the continuous smooth muscle layer is interrupted at intervals by the presence of alveoli inserted into the bronchiolar wall. Click slide 4. Although some exchange occurs in the respiratory bronchiole, it is within the alveoli of the alveolar ducts and sacs that the preponderance of gas exchange transpires. Here the walls of the alveoli, devoid of smooth muscle, are reduced in thickness to the thinnest possible juxtaposition of simple squamous alveolar cell to simple squamous capillary endothelial cell. What are the primary functions of the respiratory epithelium? What is the primary functional unit of the lung? alveoli The alveolar wall is very delicate and subject to collapse. Why is there no smooth muscle present in its wall for support? smooth muscle would hinder the gas exchange What are the three basic components of the air-blood barrier? alveolar, capillary walls and basal laminae humidfy, filter and warm incoming air Why doesn’t gas exchange occur in bronchi? bronchi have no alveoli Histology Review Supplement 129 Digestive Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Digestive Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. smooth muscle nearest the stomach, and a mix of both skeletal and smooth muscle in between. 4. The outermost layer of the esophagus is an adventitia for the portion of the esophagus in the thorax, and a serosa after the esophagus penetrates the diaphragm and enters the abdominal cavity. Click slide 3. Here we can see the abrupt change in epithelium at the gastroesophageal junction, where the esophagus becomes continuous with the stomach. Briefly explain the difference between an adventitia and a serosa. Salivary Gland The digestive process begins in the mouth with the physical breakdown of food by mastication. At the same time salivary gland secretions moisten the food and begin to hydrolyze carbohydrates. The saliva that enters the mouth is a mix of serous secretions and mucus (mucin) produced by the three major pairs of salivary glands. Click slide 1. The secretory units of the salivary tissue shown here are composed predominantly of clusters of pale-staining mucussecreting cells. More darkly stained serous cells cluster to form a demilune (half moon) adjacent to the lumen and contribute a clear fluid to the salivary secretion. Salivary secretions flow to the mouth from the respective glands through a well-developed duct system. Are salivary glands endocrine or exocrine glands? serosa secret serous fluid, and adventitia don't. Stomach The wall of the stomach has the same basic four-layered organization as that of the esophagus. Click slide 4. The mucosa of the stomach consists of a simple columnar epithelium, a thin connective tissue lamina propria, and a thin muscularis mucosa. The most significant feature of the stomach mucosa is that the epithelium invaginates deeply into the lamina propria to form superficial gastric pits and deeper gastric glands. Although the epithelium of the stomach is composed of a variety of cell types, each with a unique and important function, only three are mentioned here (see slide 5). Click slide 5. The surface mucous cells are simple columnar cells that line the gastric pits and secrete mucus continuously onto the surface of the epithelium. The large round pink- to red-stained parietal cells that secrete hydrochloric acid (HCl) line the upper half of the gastric glands; more abundant in the lower half of the gastric glands are the chief cells (not shown), usually stained blue, that secrete pepsinogen (a precursor to pepsin). Click slide 4. The submucosa is similar to that of the esophagus but without glands. The muscularis externa has the two typical circumferential and longitudinal layers of smooth muscle, plus an extra layer of smooth muscle oriented obliquely. The stomach’s outermost layer is a serosa. What is the function of the mucus secreted by surface mucous cells? exocrine Which salivary secretion, mucous or serous, is more thin and watery in consistency? serous Esophagus Through contractions of its muscular wall (peristalsis), the esophagus propels food from the mouth to the stomach. Four major layers are apparent when the wall of the esophagus is cut in transverse section: Click slide 2. 1. The mucosa adjacent to the lumen consists of a nonkeratinized stratified squamous epithelium, its immediately subjacent connective tissue (lamina propria) containing blood vessels, nerves, lymphatic vessels, and cells of the immune system, and a thin smooth muscle layer (muscularis mucosa) forms the boundary between the mucosa and the submucosa. Because this slide is a low magnification view, it is not possible to discern all parts of the mucosa nor the boundary between it and the submucosa. 2. The submucosa is a layer of connective tissue of variable density, traversed by larger caliber vessels and nerves, that houses the mucus-secreting esophageal glands whose secretions protect the epithelium and further lubricate the passing food bolus. 3. Much of the substance of the esophageal wall consists of both circumferentially and longitudinally oriented layers of muscle called the muscularis externa. The muscularis externa is composed of skeletal muscle nearest the mouth, 130 Histology Review Supplement protects the epithelium Small Intestine The key to understanding the histology of the small intestine lies in knowing that its major function is absorption. To that end, its absorptive surface area has been amplified greatly in the following ways: 1. The mucosa and submucosa are thrown into permanent folds (plicae circulares). 2. Fingerlike extensions of the lamina propria form villi (singular: villus) that protrude into the intestinal lumen (click slide 7). 3. The individual simple columnar epithelial cells (enterocytes) that cover the villi have microvilli (a brush border), tiny projections of apical plasma membrane to increase their absorptive surface area (click slide 6). Click slide 7. Although all three segments of the small intestine (duodenum, jejunum, and ileum) possess villi and tubular crypts of Lieberkuhn that project deep into the mucosa between villi, some unique features are present in particular segments. For example, large mucous glands (duodenal glands, Brunner’s glands) are present in the submucosa of the duodenum. In addition, permanent aggregates of lymphatic tissue (Peyer’s patches) are a unique characteristic of the ileum (click slide 8). Aside from these specific features and the fact that the height of the villi vary from quite tall in the duodenum to fairly short in the terminal ileum, the overall morphology of mucosa, submucosa, muscularis externa, and serosa is quite similar in all three segments. Why is it important for the duodenum to add large quantities of mucus (from the duodenal glands) to the partially digested food entering it from the stomach? Click slide 10. Located in the surrounding connective tissue, roughly at the points of the hexagon where three lobules meet, is the portal triad (portal canal). Click slide 12. The three constituents of the portal triad include a branch of the hepatic artery, a branch of the hepatic portal vein, and a bile duct. Both the hepatic artery and portal vein empty their oxygen-rich blood and nutrient-rich blood, respectively, into the sinusoids. This blood mixes in the sinusoids and flows centrally in between and around the hepatocytes toward the central vein. Bile, produced by hepatocytes, is secreted into very small channels (bile canaliculi) and flows peripherally (away from the central vein) to the bile duct. Thus, the flow of blood is from peripheral to central in a hepatic lobule, while the bile flow is from central to peripheral. What general type of cell is the phagocytic Kupffer cell? immune Blood in the portal vein flows directly from what organs? liver What is the function of bile in the digestive process? protects intestinal walls raises alkalinity to create ideal pH Colon Click slide 9. The four-layered organization is maintained in the wall of the colon, but the colon has no villi, only crypts of Lieberkuhn. Simple columnar epithelial cells (enterocytes with microvilli) are present to absorb water from the digested food mass, and the numbers of mucous goblet cells are increased substantially, especially toward the distal end of the colon. Why is it important to have an abundance of mucous goblet cells in the colon? because they secrete mucous, which is important to fascilitate degestion Pancreas Click slide 13. The exocrine portion of the pancreas synthesizes and secretes pancreatic enzymes. The individual exocrine secretory unit, or acinus, is formed by a group of pyramidal-shaped pancreatic acinar cells clustered around a central lumen into which they secrete their products. A system of pancreatic ducts then transports the enzymes to the duodenum where they are added to the lumen contents to further aid digestion. The groups of pale-staining cells are the endocrine pancreatic islet (islets of Langerhans) cells. Liver The functional tissue of the liver is organized into hexagonally shaped cylindrical lobules, each delineated by connective tissue. Click slide 11. Within the lobule, large rounded hepatocytes form linear cords that radiate peripherally from the center of the lobule at the central vein to the surrounding connective tissue. Blood sinusoids lined by simple squamous endothelial cells and darkly stained phagocytic Kupffer cells are interposed between cords of hepatocytes in the same radiating pattern. Histology Review Supplement 131 Renal Tissue Review From the PhysioEx main menu, select Histology Review Supplement. When the screen comes up, click Select an Image Group. From Group Listing, click Renal Tissue Slides. To view slides without labels, click the Labels Off button at the bottom right of the monitor. The many functions of the kidney include filtration, absorption, and secretion. The kidney filters the blood of metabolic wastes, water, and electrolytes and reabsorbs most of the water and sodium ions filtered to regulate and maintain the body’s fluid volume and electrolyte balance. The kidney also plays an endocrine role in secreting compounds that increase blood pressure and stimulate red blood cell production. The uriniferous tubule is the functional unit of the kidney. It consists of two components: the nephron to filter and the collecting tubules and ducts to carry away the filtrate. Click slide 1. The nephron itself consists of the renal corpuscle, an intimate association of the glomerular capillaries (glomerulus) with the cup-shaped Bowman’s capsule, and a single elongated renal tubule consisting of segments regionally and sequentially named the proximal convoluted tubule (PCT), the descending and ascending segments of the loop of Henle, and the distal convoluted tubule (DCT). Click slide 2. A closer look at the renal corpuscle shows both the simple squamous epithelium of the outer layer (parietal layer) of the glomerular capsule (Bowman’s capsule) and the specialized inner layer (visceral layer) of podocytes that extend footlike processes to completely envelop the capillaries of the renal glomerulus. Processes of adjacent podocytes interdigitate with one another, leaving only small slits (filtration slits) between the processes through which fluid from the blood is filtered. The filtrate then flows into the urinary space that is directly continuous with the first segment of the renal tubule, the PCT. The PCT is lined by robust cuboidal cells equipped with microvilli to greatly increase the surface area of the side of the cell facing the lumen. Click slide 3. In the loop of Henle, lining cells are simple squamous to simple cuboidal. The DCT cells are also simple cuboidal but are usually much smaller than those of the PCT. The sparse distribution of microvilli, if present at all, on the cells of the DCT relates to their lesser role in absorption. The DCT is continuous directly with the collecting tubules and collecting ducts that drain the filtrate out of the kidney. The large renal artery and its many subdivisions provide an abundant blood supply to the kidney. The smallest distal branches of the renal artery become the afferent arterioles that directly supply the capillaries of the glomerulus. In a unique situation, blood from the glomerular capillaries passes into the efferent arteriole rather than into a venule. The efferent arteriole then perfuses two more capillary beds, the peritubular capillary bed and vasa recta that provide nutrient blood to the kidney tissue itself, before ultimately draining into the renal venous system. In which segment of the renal tubule does roughly 75–80% of reabsorption occur? proximal convoluted tubules How are proximal convoluted tubule (PCT) cells similar to enterocytes of the small intestine? both absorb water, salts, vitamins, phosphates Starting from inside the glomerular capillary through to the urinary space, what are the three layers through which the filtrate must pass? glomerular capillary enothelium, glomrular basement membrane visceral layer of bowman's capsule Under normal circumstances in a healthy individual, would red blood cells or any other cells be present in the renal filtrate? no In addition to providing nutrients to the kidney tubules, what is one other function of the capillaries in the peritubular capillary bed? they deliver blood to tubular sites 132 Histology Review Supplement

The Influence of Public Health and Safety Matters on the Invention of the City

Towns are and were ever associated with trade and power [ R1 ] . Although towns every bit good as worlds have to develop. They were formed and shaped by Numberss of assorted factors. This essay would demo how have public wellness and safety affairs in the yesteryear influenced the innovation of the metropolis? One of the really first and obvious that come to mind are rigorous British fire ordinances, clearly and justly linked by most to the Great Fire of London. In its history London as a metropolis had great sums of fires in its history. One of first terrible recorded fires of London happened in 1135. It put down most of the metropolis between St Paul ‘s and St Clement Danes in Westminster every bit good as celebrated London Bridge. â€Å"Little admiration London suffered from fires: lodging and commercial premises existed together ; a Norman jurisprudence banned house fires after dark, but was likely ignored ; edifices were mostly made of wood and thatch ; and no organized fire brigade existed.† ( The 12th of July 1212 AD, Great Fire of London 1212, n.d. ) . It took good over 70 old ages and another immense fire, on 12th July 1212. This fire and figure of 3000 deceases, still appears in the Guinness Book of Records, even though possibly overdone. Those fires caused people to see about edifice regulations. In consequence ‘legislations’ every bit good as methods to stay them were introduced. Crude and really first signifier of fire protection was something every bit simple as censoring thatched roofs in full London. By its first city manager Henry Fitzailwin. He besides signed a papers stating: â€Å"Complaints about edifice nuisances could be brought by one neighbor against another. The city manager and aldermen settled such instances in a tribunal called the Assize of Nuisance† . Opinions were advised by appointed Masons and carpenters. ( History of Building Regulations in the British Isles, 2014 ) Other British metropoliss started follow London’s lead. The existent turning point in constructing history was fire of 1666. [ R2 ] F anger known as the Great Fire of London started in the bakeshop on Pudding Lane and really shortly started distributing west making beyond Roman metropolis walls. On 4th September wind way changed, it headed and about reached the Tower of London. During the firefighting procedure â€Å"King Charles II personally helped contend the fire. He lifted pails of H2O and threw money to honor people who stayed to contend the flames.† ( Museum of London – Frequently asked inquiries, n.d. ) Quenching the fire is considered to hold been successful due two factors: the strong east air currents died down, and the Tower of London fort used gunpowder to make fireguards, and halt further spread eastward. ( Great Fire of London – Wikipedia, the free encyclopaedia, n.d. ) . It’s believed that as a effect of this fire 80 % of capital was burned to the land. Inevitably catastrophe of this graduated table couldn’t go on once more. Therefore London Rebuilding Act of 1667 was introduced. [ R3 ] This papers created foundations of city/master planning every bit good as some other countries of modern edifice ordinances. Was the really first to stipulate how metropolis planning was to be regulated ( i.e. Certain streets need to be broad depending on strength and intent of usage ) . It was depicting what affairs and how they should be resolved by Judgess. Besides stipulating thickness and location of walls, including party walls. It introduced the thought of the committee planing cityscape every bit good as committee to O.K. location and form, every bit good as stuffs used in new edifices. All edifices from that point onwards were to be built of brick or rock. It besides regulated minor issues like precipitation direction, maximal overhangs, which antecedently were doing already narrow streets even narrower and tighter. That was debut to the thought of more pleasant metropoliss, even though done for practical grounds. Some more wellness and safety regulations were issued. [ R4 ] Even though this jurisprudence was highly precise for that clip. It was written by local authorities of London and was to be obeyed merely during reconstructing of the metropolis. As consequence of that British Isles were left without public jurisprudence. In 1898 Ebenezer Howard initiated â€Å"The Garden City Movement† . Garden metropoliss were designed and intended to be self-contained, self-sufficing communities. Separated and surrounded by paths of unfastened, green countries. Taking inspiration and seeking to do a Utopian dream of Sir Thomas More come truth. Howard’s idealise garden metropolis was utilizing clear districting system. Keeping residential and industrial development countries separate, allowed â€Å"smokeless† thought of the metropolis to develop. They would be populated by 32000 people on around 6000 estates ( 2400 hour angle ) . Planned in concentric circles, when to the full populated another garden metropolis would develop nearby. Several o f these would be clustered ‘orbiting’ around the cardinal metropolis ( populated by 50000 people ) . [ R5 ] â€Å"The Garden City Association set itself the ambitious undertaking of developing a first garden metropolis. Work on the chosen site at Letchworth began in 1903 and by 1914 it housed 9,000 inhabitants.† ( The birth of town be aftering – UK Parliament, n.d. ) Letchworth was really advanced and successful, it populated 33500 people. It was perchance impractical to utilize homocentric program, although rules were kept. Letchworth introduced traffic circle ( 1909 ) and was really first illustration of ‘green belt’ . This undertaking didn’t require empowering statute laws, although it was inspirational to â€Å"garden suburbs† . These were foremost introduced in Hampstead. Endorsed by Parliament in 1906, in what has been called â€Å" Hampstead Garden Suburb Act [ R6 ] † . This papers legislated that distance between the two houses on opposite sides of the route, were to be non less than 50 pess ( 15.24m ) apart. And that there sho uld be no more than 8 houses per acre ( 4046.9m2) . [ R7 ] ‘Back-to-back’ houses, so popular in industrial Victorian developments. During the industrial revolution â€Å"great inflow of workers and their households into the quickly industrialized towns during the 1800 ‘s, this figure increased massively and the jobs of over-population became disastrous† ( Public Health – History of medical specialty, n.d. ) . This was revealed by the study of Liverpool ‘s first medical officer of wellness ( Dr Duncan ) . It stated that – tierce of the metropolis ‘s population lived on Earth floored basements of dorsum to endorse houses. ( The birth of town be aftering – UK Parliament, n.d. ) Without any airing and sanitation with every bit many as 16 people populating in one room, these were certainly non what those basements were designed for and what they could defy. They were made illegal in 1909 due to Housing and Town Planning Act, as there was concern that it could be the starting motor of the new concatenation reaction consequence of pestilence for illustration similar in consequence to London’s Great Fire. [ R8 ] Letchworth and Hampstead was the chief inspiration for that 1909 Act. It besides took inspiration of garden metropolis motion rules. Not a surprise that the Garden City Association actively lobbied for it. This besides encouraged to utilize ‘Garden City’ rules. Leading the manner to the more gratifying urban environment and more flexibleness in footings of design. This act obligated local governments to utilize town planning, and control edifice criterions. Specified the occupation of local authoritiess on what they can and can’t do. The new jurisprudence formed the usher on how to be after metropoliss and how to construct safely. It besides specified land jurisprudence, how and where working category lodging should be built. Besides, sing wellness and safety of citizens and future occupants, which could be named as a signifier of sustainable design. [ R9 ] As before mentioned planning jurisprudence has been altering and accommodating for past old ages. Even though fire ordinances in the UK are perchance one of the strictest in Europe. As statistics show there is a batch of betterment to be made. World of be aftering needs people like Ebenezer Howard, dreamer and dreamers that design, program and better urban and universe environment – in consequence devising universe more gratifying. In modern metropoliss chief perplexity are sustainability and public wellness. It’s non easy to diminish fleshiness and other so called civilisation diseases. The rate of these could be lowered by extinguishing factors that do or may do it. The chief 1s being: deficiency of physical activity, unnatural/unhealthy diet, polluted air and some more (Diseases of modern civilization — Frank Fenner Foundation, n.d. ) . These may and should be considered at design phase. To better physical activity. It’s necessary to increase the sum of public conveyance used, every bit good as addition sum of resort areas. Enhancing physical activity from early old ages, followed by pathwaies, Parkss or other green countries. Obviously there is really small interior decorator or designer can make about human diet. However, what could be done is to plan green markets into town flower stalk. These would do fresh, of course grown, healthy fruits/vegetables effortlessly accessible. Another in theory unaccessible country for urban contrivers is air pollution, as we can’t actively decrease pollution. Already Ebenezer Howard has suggested to utilize town districting to travel industrial enlargement out on the fringes of towns. In the long term this would diminish the sum of contaminated air in towns, by administering it more equally across unfastened countries, and most likely lower the urban island consequence. All of those illustrations show how past events were set uping town planning. It proves that there is a set of ingredients and stimulations. They all consequence be aftering jurisprudence and planning methods. Urban environment is ever altering and it is difficult to plan it good. This is why there are groups of urban contrivers, designers, interior decorators and others working to better the design of towns. This has been altering for 100s, or even 1000s of old ages, and they would be. Changes are inevitable, what is now countryside in 10 old ages, or even less could be new suburbs. This should excite interior decorators and visionaries to better interior urban flower stalk, decide current and anticipate hereafter issues and turn to them today. BBC – History – British History in deepness: London After the Great Fire( n.d. ) . [ Online ] [ Accessed on 26th December 2014 ] hypertext transfer protocol: //www.bbc.co.uk/history/british/civil_war_revolution/after_fire_01.shtml. ‘Building Regulations – David Watkins.pdf’ ( n.d. ) . Diseases of modern civilization — Frank Fenner Foundation( n.d. ) . [ Online ] [ Accessed on 1st January 2015 ] hypertext transfer protocol: //www.natsoc.org.au/our-projects/biosensitivefutures/part-4-facts-and-principles/human-health-issues/diseases-of-modern-civilisation. English Historical Fiction Writers: Changing the Face of London – the Great Fire of 1666( n.d. ) . [ Online ] [ Accessed on 26th December 2014 ] hypertext transfer protocol: //englishhistoryauthors.blogspot.co.uk/2013/05/changing-face-of-london-great-fire-of.html. Great Fire of London – Wikipedia, the free encyclopaedia( n.d. ) . [ Online ] [ Accessed on 27th December 2014 ] hypertext transfer protocol: //en.wikipedia.org/wiki/Great_Fire_of_London. Handbook to the Housing and Town Planning Act, †¦( n.d. ) . [ Online ] [ Accessed on 27th December 2014 ] hypertext transfer protocol: //archive.org/stream/handbooktohousin00thom # page/n1/mode/2up. History of Building Regulations in the British Isles( 2014 ) . [ Online ] [ Accessed on 14th December 2014 ] hypertext transfer protocol: //www.buildinghistory.org/regulations.shtml. History of Building Regulations in the British Isles( n.d. ) . [ Online ] [ Accessed on 26th December 2014 ] hypertext transfer protocol: //www.buildinghistory.org/regulations.shtml. Housing, town planning, etc. , act, 1909 ; a prac†¦( n.d. ) . [ Online ] [ Accessed on 27th December 2014 ] hypertext transfer protocol: //archive.org/stream/housingtownplann00bent # page/n5/mode/2up. London Fire Brigade – The Great Fire of London( n.d. ) . [ Online ] [ Accessed on 26th December 2014 ] hypertext transfer protocol: //www.london-fire.gov.uk/great-fire-of-london.asp. Museum of London – Frequently asked inquiries( n.d. ) . [ Online ] [ Accessed on 26th December 2014 ] hypertext transfer protocol: //archive.museumoflondon.org.uk/Londons-Burning/FAQ/ . Museum of London – The 1667 Rebuilding Act( n.d. ) . [ Online ] [ Accessed on 27th December 2014 ] hypertext transfer protocol: //archive.museumoflondon.org.uk/Londons-Burning/Themes/1405/1408/Page1.htm. Public Health – History of medical specialty( n.d. ) . [ Online ] [ Accessed on 29th December 2014 ] hypertext transfer protocol: //www.priory.com/history_of_medicine/public_health.htm. Samuel Pepys Diary 1666 – Fire of London( n.d. ) . [ Online ] [ Accessed on 27th December 2014 ] hypertext transfer protocol: //www.pepys.info/fire.html. The 12th of July 1212 AD, Great Fire of London 1212( n.d. ) . [ Online ] [ Accessed on 27th December 2014 ] hypertext transfer protocol: //www.information-britain.co.uk/famdates.php? id=1019. The birth of town be aftering – United kingdom Parliament( n.d. ) . [ Online ] [ Accessed on 28th December 2014 ] hypertext transfer protocol: //www.parliament.uk/about/living-heritage/transformingsociety/towncountry/towns/overview/townplanning/ . The Geneva Association ( 2014 ) ‘World Fire Statistics.’ The Hampstead Garden Suburb Act 1906( n.d. ) . [ Online ] [ Accessed on 28th December 2014 ] hypertext transfer protocol: //www.hgs.org.uk/history/h00012000.html.

Baseball and Statistics

Baseball is the era of America in the past. The two fields are not identical. The only part of the baseball stadium in your league is Uchino. Each Major League baseball park is a quadrilateral square with a size of exactly the same size as Uchino and a size of 9 feet on both sides. According to the rules of the league, the league determines the size of the ball and the baseball gloves, the baseball game uses wooden sticks or metal bats between the two teams. At the beginning of the game, the home team first participated in the competition. Sabremetrics refers to the development of statistical studies of baseball and the development of new statistical and analytical tools. This term is also used to directly reference the new statistics themselves. This term was built by Bill James, one of the main supporters in this field around 1980, born from the American Baseball Research Association (SABR). The basic percentage measures the basic ability of the batter. It is calculated by dividing the total of batters' batting (hitting plus walking and ball hitting) with the batter's full board appearance (blow plus walking and coat plus sacrifice). (Fly), in addition to sacrificing shorts It is also called Moneyball. Actual database management. An attractive story, geek covers the baseball field (literally not). Statistics has changed into a baseball reconnaissance method: the industry has completely ignored the traditional wisdom that he did not follow for decades and began studying numbers. This is a universal scientific story about emotions that every otaku recognizes. Randomness is an excellent book on probability. We carefully study opportunities through its role in human history, its perspective on philosophy and religion, and its modern application in technology. In similar books, it is unusual for mathematical problems to be explained by the fluency of the human tongue. Baseball statistics have been developed over the years. Early baseball statistics were only aimed at recalculating what happened, but the surveyor realized that statistics could be used to predict future events. As a result, in the latter part of the 20th century, a wave of new statistics has emerged to keep the player's value more accurately predicted. The work of James, Dewan, Ricky, Palmer's military investigators has laid the foundation for teams to adopt similar ideas and strategies when creating lists and deciding games. Front desk also takes advantage of the inefficiency of in-game and foreground strategies, as the military school staff at that time recognized the flaws in current player evaluation methods and created new statistics to address known shortcomings did. Baseball and Statistics Baseball is the era of America in the past. The two fields are not identical. The only part of the baseball stadium in your league is Uchino. Each Major League baseball park is a quadrilateral square with a size of exactly the same size as Uchino and a size of 9 feet on both sides. According to the rules of the league, the league determines the size of the ball and the baseball gloves, the baseball game uses wooden sticks or metal bats between the two teams. At the beginning of the game, the home team first participated in the competition. Sabremetrics refers to the development of statistical studies of baseball and the development of new statistical and analytical tools. This term is also used to directly reference the new statistics themselves. This term was built by Bill James, one of the main supporters in this field around 1980, born from the American Baseball Research Association (SABR). The basic percentage measures the basic ability of the batter. It is calculated by dividing the total of batters' batting (hitting plus walking and ball hitting) with the batter's full board appearance (blow plus walking and coat plus sacrifice). (Fly), in addition to sacrificing shorts It is also called Moneyball. Actual database management. An attractive story, geek covers the baseball field (literally not). Statistics has changed into a baseball reconnaissance method: the industry has completely ignored the traditional wisdom that he did not follow for decades and began studying numbers. This is a universal scientific story about emotions that every otaku recognizes. Randomness is an excellent book on probability. We carefully study opportunities through its role in human history, its perspective on philosophy and religion, and its modern application in technology. In similar books, it is unusual for mathematical problems to be explained by the fluency of the human tongue. Baseball statistics have been developed over the years. Early baseball statistics were only aimed at recalculating what happened, but the surveyor realized that statistics could be used to predict future events. As a result, in the latter part of the 20th century, a wave of new statistics has emerged to keep the player's value more accurately predicted. The work of James, Dewan, Ricky, Palmer's military investigators has laid the foundation for teams to adopt similar ideas and strategies when creating lists and deciding games. Front desk also takes advantage of the inefficiency of in-game and foreground strategies, as the military school staff at that time recognized the flaws in current player evaluation methods and created new statistics to address known shortcomings did. Baseball and Statistics Baseball is the era of America in the past. The two fields are not identical. The only part of the baseball stadium in your league is Uchino. Each Major League baseball park is a quadrilateral square with a size of exactly the same size as Uchino and a size of 9 feet on both sides. According to the rules of the league, the league determines the size of the ball and the baseball gloves, the baseball game uses wooden sticks or metal bats between the two teams. At the beginning of the game, the home team first participated in the competition. Sabremetrics refers to the development of statistical studies of baseball and the development of new statistical and analytical tools. This term is also used to directly reference the new statistics themselves. This term was built by Bill James, one of the main supporters in this field around 1980, born from the American Baseball Research Association (SABR). The basic percentage measures the basic ability of the batter. It is calculated by dividing the total of batters' batting (hitting plus walking and ball hitting) with the batter's full board appearance (blow plus walking and coat plus sacrifice). (Fly), in addition to sacrificing shorts It is also called Moneyball. Actual database management. An attractive story, geek covers the baseball field (literally not). Statistics has changed into a baseball reconnaissance method: the industry has completely ignored the traditional wisdom that he did not follow for decades and began studying numbers. This is a universal scientific story about emotions that every otaku recognizes. Randomness is an excellent book on probability. We carefully study opportunities through its role in human history, its perspective on philosophy and religion, and its modern application in technology. In similar books, it is unusual for mathematical problems to be explained by the fluency of the human tongue. Baseball statistics have been developed over the years. Early baseball statistics were only aimed at recalculating what happened, but the surveyor realized that statistics could be used to predict future events. As a result, in the latter part of the 20th century, a wave of new statistics has emerged to keep the player's value more accurately predicted. The work of James, Dewan, Ricky, Palmer's military investigators has laid the foundation for teams to adopt similar ideas and strategies when creating lists and deciding games. Front desk also takes advantage of the inefficiency of in-game and foreground strategies, as the military school staff at that time recognized the flaws in current player evaluation methods and created new statistics to address known shortcomings did. Baseball and Statistics Baseball is the era of America in the past. The two fields are not identical. The only part of the baseball stadium in your league is Uchino. Each Major League baseball park is a quadrilateral square with a size of exactly the same size as Uchino and a size of 9 feet on both sides. According to the rules of the league, the league determines the size of the ball and the baseball gloves, the baseball game uses wooden sticks or metal bats between the two teams. At the beginning of the game, the home team first participated in the competition. Sabremetrics refers to the development of statistical studies of baseball and the development of new statistical and analytical tools. This term is also used to directly reference the new statistics themselves. This term was built by Bill James, one of the main supporters in this field around 1980, born from the American Baseball Research Association (SABR). The basic percentage measures the basic ability of the batter. It is calculated by dividing the total of batters' batting (hitting plus walking and ball hitting) with the batter's full board appearance (blow plus walking and coat plus sacrifice). (Fly), in addition to sacrificing shorts It is also called Moneyball. Actual database management. An attractive story, geek covers the baseball field (literally not). Statistics has changed into a baseball reconnaissance method: the industry has completely ignored the traditional wisdom that he did not follow for decades and began studying numbers. This is a universal scientific story about emotions that every otaku recognizes. Randomness is an excellent book on probability. We carefully study opportunities through its role in human history, its perspective on philosophy and religion, and its modern application in technology. In similar books, it is unusual for mathematical problems to be explained by the fluency of the human tongue. Baseball statistics have been developed over the years. Early baseball statistics were only aimed at recalculating what happened, but the surveyor realized that statistics could be used to predict future events. As a result, in the latter part of the 20th century, a wave of new statistics has emerged to keep the player's value more accurately predicted. The work of James, Dewan, Ricky, Palmer's military investigators has laid the foundation for teams to adopt similar ideas and strategies when creating lists and deciding games. Front desk also takes advantage of the inefficiency of in-game and foreground strategies, as the military school staff at that time recognized the flaws in current player evaluation methods and created new statistics to address known shortcomings did. Baseball and Statistics Baseball is the era of America in the past. The two fields are not identical. The only part of the baseball stadium in your league is Uchino. Each Major League baseball park is a quadrilateral square with a size of exactly the same size as Uchino and a size of 9 feet on both sides. According to the rules of the league, the league determines the size of the ball and the baseball gloves, the baseball game uses wooden sticks or metal bats between the two teams. At the beginning of the game, the home team first participated in the competition. Sabremetrics refers to the development of statistical studies of baseball and the development of new statistical and analytical tools. This term is also used to directly reference the new statistics themselves. This term was built by Bill James, one of the main supporters in this field around 1980, born from the American Baseball Research Association (SABR). The basic percentage measures the basic ability of the batter. It is calculated by dividing the total of batters' batting (hitting plus walking and ball hitting) with the batter's full board appearance (blow plus walking and coat plus sacrifice). (Fly), in addition to sacrificing shorts It is also called Moneyball. Actual database management. An attractive story, geek covers the baseball field (literally not). Statistics has changed into a baseball reconnaissance method: the industry has completely ignored the traditional wisdom that he did not follow for decades and began studying numbers. This is a universal scientific story about emotions that every otaku recognizes. Randomness is an excellent book on probability. We carefully study opportunities through its role in human history, its perspective on philosophy and religion, and its modern application in technology. In similar books, it is unusual for mathematical problems to be explained by the fluency of the human tongue. Baseball statistics have been developed over the years. Early baseball statistics were only aimed at recalculating what happened, but the surveyor realized that statistics could be used to predict future events. As a result, in the latter part of the 20th century, a wave of new statistics has emerged to keep the player's value more accurately predicted. The work of James, Dewan, Ricky, Palmer's military investigators has laid the foundation for teams to adopt similar ideas and strategies when creating lists and deciding games. Front desk also takes advantage of the inefficiency of in-game and foreground strategies, as the military school staff at that time recognized the flaws in current player evaluation methods and created new statistics to address known shortcomings did.

Impressionist Art Essay Example | Topics and Well Written Essays - 750 words

Impressionist Art - Essay Example While other movement before Impressionism attempted to capture reality as static images, the Impressionist painters, and later the composers, tried to show the nature of reality through the fluctuation and change in light, tone and color. During the late nineteenth and early twentieth centuries a group of artists united in an attempt to create a new style and technique of art based on direct observation of reality and to a subjective impression or mood of reality. This is evident from the emotional moods that are so eloquently captured in this exhibition. Many of the paintings reveal the success of their attempts and the resulting masterpieces of Impressionism. For example, Claude Monet's Haystacks is a work that no student or lover of modern art should miss. During the 1870's Monet developed his unique technique for painting atmospheric light rendered by means of rhythmic and broken brush strokes. This painting is an example of the impressionist aim of capturing transitory nature by means of direct observation. In Haystacks (1891) Monet succeeds in creating solid geometric shapes with nuances of light and color. The presentation of light and color is one of the most beautiful things about this type of art, and demonstrates the overall beauty behind this movement. Emotion in art was not a focus; rather the atmosphere and look of the painting expressed the beauty of the picture overall. Music is another medium where the beauty behind this period truly stands out. During this time period, classical music as mostly influenced in France toward the end of the nineteenth and through the twentieth century. The focus within the music was on both atmosphere and suggestion, and not necessarily on strong emotion or the presentation of a story, generally presented in program music. Much of this music, like the art, was a reaction against Romanticism, and the focus of Impressionist music was to use a sort of dissonance as well as uncommon scales. This is comparable to the impressionist style of painting, in which, when one stands close up, one sees the dissonance of the picture. However, the dissonance and difference is what creates the general attraction and beauty in the music itself. Claude DeBussy is an example of a successful Impressionist composer. His music in The Three Nocturnes includes characteristic studies in veiled harmony and texture, creating an overall atmospher e of difference, but this difference creates a feeling of respect and beauty. The work itself is not a usual nocturne, but is given to create the impression of the effects light would suggest. This includes the motion of the clouds as well, as they fade away with the sound of the music. The background of the piece remains consistent, thus blending music into a kind of cosmic rhythm. Therefore, both the works of DeBussy and Monet present the beauty behind this time period. Although this movement had its focus on creating "impressions" of the real thing, there was a great deal of beauty and talent that went into creating those impressions. The result in the case of art is a beautiful combination and focus on light within one's visual aspect, and within music, one is able to experience the feeling and movement of life by listening to music. Therefore, both of these concepts present

In changes brought by contemporary globalization,in cultural terms,who Essay

In changes brought by contemporary globalization,in cultural terms,who wins and who who loses - Essay Example These changes, though, are the subject of increasing debate. Some find the cultural trends disturbing and dangerous while others praise them as humanity’s march toward a more harmonious and efficient world order. This essay will assume neither approach; the sole purpose of this essay is to identify the winners and the losers in this period of cultural upheaval and change. It will be left for others to decide the implications. As a preliminary matter, cultural globalization most generally refers to the expansion of cross-cultural contacts and relationships. Relationships may be passive or they may be active (Tomlinson, 1999; 14). Passive cross-cultural contacts refer to the receipt of new cultural information and behaviours. There is little interactivity in this regard. For purposes of illustration, this may involve reading foreign newspapers on the internet, watching foreign music videos in the home, or using textbooks written by foreign authors in schools. Active cross-cultural contacts are characterised by interactivity, a real relationship which is established, and is more prone to conflict; being more prone to conflict, therefore, an adversarial context is more likely to arise in a cultural sense and it is here where the winners and the losers are most visible. This might involve the implementation of European standards of corporate social responsibility in Asian countries unaccustomed to such notion s of corporate culture. This might involve tensions caused by the proliferation of non-governmental organizations in countries whose political culture tolerates no extra-governmental criticism or dissent. Both forms of cultural globalization, active and passive, are influential. That said, the biggest winners and the biggest losers tend to be most visible in settings of active cross-cultural globalization. Some of the biggest winners are those whom align themselves with those whom have the power and the desire to homogenise their

Global Trends and my Career Essay Example | Topics and Well Written Essays - 500 words

Global Trends and my Career - Essay Example The duty of protecting the soil of the country as well as the well being of the citizens lies on the shoulders of the military and hence this will call for more responsibilities to be carried by the officials of the military and other concerned agencies. I am pursuing my career as a federal employee in the administration department of the military. Hence these global trends for the next decade, which will affect the world and the United States, will also serve to have an impact on my career. The military is being more technologically advanced so as to meet the requirements of the fast paced world. This serves to be of assistance but attacks on the technological systems can greatly alter the working capacity and potential. As a part of the administration, we will have to work towards investing more on upgrading our technological system. Proper planning will be required for implementation of these programs as well. The integration of the different departments that lie in the military will be done. Considering these factors, I will need to have a proper training program with regard to technology and my staff will need to be trained as well. The military members will also require training so that the whole system works effectively towards providing a better output. As a member of the administration, more responsibilities will lie on us to protect the technological systems from the potential threats that may lead to alter and disrupt the normal functioning and activities of the military as a whole. Hence, I will need to achieve a better level of understanding with regards to the new technology and stand as a good administrator to be of help at all levels. This shows that my career will be oriented towards achieving more expertise and knowledge. The American fight against terrorism will go on according to the global trends and hence it will result in America being a target by these terrorists. The infrastructure of the country as well as the life of its

Childrens products Essay Example | Topics and Well Written Essays - 3000 words

Childrens products - Essay Example It is for this reason that 8% teenagers of the United States have some portion of their money invested in futures and stocks (Lindstorm, 2004). Almost 20% have their personal checking accounts and 70% love using a credit card if the parents allow it (Lindstorm, 2004). It is hard to argue that global kids segment does not exist when this generation spends over $150 billion a year. And that is not it, they also control another $150 billion through influencing what their parents are buying for them. Martin Lindstorm writes in Brainchild that the money which the new generation is spending is unprecedented, which is why every marketing director needs to allot money for this niche (Sudworth, Cray and Russel, 2007). The 21st century is full of information overload. The new generation is being fed a steady diet of information 24 seven. This information is changing the way they perceive the world and shaping their behavior. The global kids segment is the product of technological advancements. They use mouse, computer screens, smart phones, tablets and other gadgets to see the world. Toddlers now understand icons before they can even start to read. Smart phone manufacturers and app developers specifically target their marketing strategies to toddlers. They can play with the smart phone, listen to the funny sounds but they do not know that the icons and marketing tactics are targeting their subconscious and effecting their decision-making behaviors. The new generation thinks in terms of megabytes and screen resolutions the same way the previous generation used to think in terms of memorizing football scores and doing wheelies on bicycles (Lindstorm, 2004). If the marketing directors need to target global kids’ segment they need to think the way this generation thinks. They need to understand that the new generation is very different from the older generation because they have no hindrances in fully embracing the digital media. Electronic media has

INVESTIGATE A FAMILY VIOLENCE TOPIC AT A NATIONAL LEVEL Research Paper

INVESTIGATE A FAMILY VIOLENCE TOPIC AT A NATIONAL LEVEL - Research Paper Example (Severson, 2011) It was reported in the Seattle Times on April 2, 2007 that Rebecca Griego was â€Å"stalked and murdered at the University of Washington by an abusive ex-boyfriend, who then killed himself.† (Carr, et al, 2007) It was reported by The New York Times on the 10th day of April 2011 that a woman was killed by her boyfriend who inflicted multiple stab wounds. Neighbors heard her screaming but by the time the police located her it was too late. An article published in The New Citizens Press October 23, 2009 reports that in 2007 45 individuals were killed in Michigan in domestic violence related homicides in Michigan. The weapons of choice is stated to have been a firearm and over 50% of the victims were killed by a firearm and 25% of the victims were killed by being stabbed. In 40% of the cases, the relationship had ended or was going to end. Most of the cases had a prior history of domestic violence, all except two of the domestic homicides were perpetrated by males . It was reported January 27, 2010 by the Houston Chronicle that the pastor of a church located in the area of Houston had been accused of domestic violence. The victim was the pastor’s estranged wife.

Employee Compensation Essay Example | Topics and Well Written Essays - 1000 words

Employee Compensation - Essay Example This essay stresses that organizations that are since committed to developing a compensation system that is designed around performance will want to consider the use of incentive pay. Typically given in addition to-rather than in place of-the basic wage, incentive plans should be viewed as an additional dimension to the wage structure. Incentives can be paid based on individual, group, or organization wide performance – a pay-for-performance concept. This paper makes a conclusion that the compensation structure consists of lavishing exorbitant sums on management level while penny-pinching on pay for other workers. This is an example of a harmful business model. The company can, and should narrow its pay gap by bringing down the top – and lifting the bottom up. It has a pay for performance plan for the management level employees. This is strength of the compensation structure but this need to be stretched out to the entire workforce so that the weakness exhibited by way of the huge executive compensation. To conclude, instead of cutting down on the executive compensation package, it would be beneficial if an opportunity is given to enter the profit sharing plan allowing employees to share in the success of a firm by distributing part of the company’s profits back to the workers. In essence, employees become owners of the company. The logic behind profit-sharing plans is that they increase commitment and loyalty to th e organization.

Coffee Industry Essay Example for Free

Coffee Industry Essay People usually drink coffee to stay up while awake at night, besides that many people rely on coffee to get their day started. According to the New England Journal of Medicine, â€Å"Drinking coffee can lead to a longer life†; however, many consumers have no idea of the impact of habits on their coffee and coffee farmers around the globe, ethical issues of consumers with the industry is not fair; but to coffee farmers, the issues are human rights violations and use of child labor issues need to be addressed. To remedy this situation, the fair trade will hopefully improve the living conditions of some of the poorest people in the world through certified value and the change in the consumers choice. Coffee is one of the most valuable commodities in the world, most of the farmers in the form of small retail and come from developing countries, although the majority of coffee sales are in the America and Europe many people around the world rely on coffee to work and have a better life; however, to producing quality coffee, farmers have to work very hard though farmers receive very little money and the inequity of the coffee producing companies when they sell coffee. Working conditions of farmers in the plantations are very different, although they work hard , but it paid for exploitation, for example , in Guatemala , coffee pickers to harvest 100 pounds to get the minimum wage $ 3 per day (The Problem with Fair Trade Coffee 2010),farmers have to work overtime and do not earn extra money, so farmers use child labor for the production of coffee to save money and use these chemicals effect of the human body in order for a fast development of coffee sale on the market. Moreover, using the chemicals and the development of the coffee industry adversely affect habitat and species decline. In addition, forests are cut down to coffee production affects the environment and soil erosion. According to World Wildlife Fund (WWF), â€Å"converting forest to tea and coffee agriculture can also create erosion and soil loss† (WWF 2010) ; Yet the farmers have no choice and/or the opportunity to change. According to the International Coffee Organization or ICO â€Å"Coffee production in 2012 was 144 611 000 bags, mostly from less developed countries such as, Brazil 50 826 000 bags ,Vietnam 22 000 000 bags and Indonesia 12 730 000 bags â€Å" (ICO 2013), though coffee production is highly ranked in the world, but farmers still do not get enough money to pay for life, for example. Vietnam in 2012, producing nearly 30 % of world coffee production but the turnover is only 10 % of the total trade value obtained from the global industry, the main reason is due to their ability to improve processing of value and coffee products are limited, coffee roasting plants in countries with rates lower than 10%, when farmers sells 1kg of coffee beans, farmers gets about 2 dollars or an average price of one cup of coffee oversea, yet 1 kg of coffee can make 50 cups. In addition, the links between farmers and enterprises are not strong, the lack of information on farmers markets, so farmers often extorted. Moreover, the risk of crop failure is the fear of the coffee growers. Most of the profits from coffee for export processing enterprises, coffee farmers only enjoy a small percentage. That has caused insecurity for farmers. Solution to this problem is the fair trade. According to Wikimedia, Fair trade coffee is coffee that is certified as having been produced and marketed to a stated set of standards. Many Customers pay a higher price when buying coffee with the certification logo or brand in the Belief Furniture , by doing so, they are helping farmers in the Third World . In particular, the fair trade coffee movement gives a reasonable price to the Farmers who were being a low wage labor exploitation. However, achieve certification of fair trade, farmers must meet several conditions of production as farmers have to meet a large variety of production standards : there are limits on the use of child labor , pesticides , herbicides , genetically modified products , etc. With these standards met, both consumers and farmers can benefit, with farmers getting the sufficient amount of money for their products, and the consumers getting their product knowing it’s safe to consume and has no effect on the producers financially or ethnically. These farmers must cooperate with businesses to produce the certified products, such amounts received will be higher and the lives of the farmers would be better. In addition, consumers should choose certified products in the supermarket or the market as this will support and will be helpful for farmers. In conclusion, fair trading is the way for farmers and coffee producers to get a higher amount, and will change lives for the better. Therefore farmers should choose fair trade to ensure benefits and consumers should choose products that have been certified to support the farmers. Reference * The problem with Fair Trade Coffee. * Retrieved August 30, 2013, from http://www. ssireview. org/articles/entry/the_problem_with_fair_trade_coffee * Coffee Production and Labor. * Retrieved August 30, 2013, from http://www. organicconsumers. org/starbucks/coffeelabor. htm * Fair Trade Coffee * Retrieved August 30, 2013, from http://en. wikipedia. org/wiki/Fair_trade_coffee * International Coffee Organization- EXPORTING COUNTRIES: TOTAL PRODUCTION * Retrieved August 30, 2013, from http://www. ico. org/prices/po. htm. * Health and effect of Coffee * Retrieved August 30, 2013, from http://en. wikipedia. org/wiki/Health_effects_of_coffee * Environmental Impacts of Coffee and Tea Production * Retrieved September 2, 2013 from http://www. hellogreentomorrow. com/blog/2010/11/environmental-impacts-of-coffee-and-tea-production.

Biflavone and a Plant Sterol Isolated from Antidesma bunius

Biflavone and a Plant Sterol Isolated from Antidesma bunius A Biflavone and a Plant Sterol Isolated from Antidesma bunius (Linn.) Spreng. Ivan L. Lawagai,* Suad Naheedb, Mohammed Mosihuzzamanc, Allan, Patrick G. Macabeoadeg, Erickson Paragasefk, Peter Prokschh, Alicia M. Aguinaldoaeg Keywords: Antidesma, Antidesma bunius, Amentoflavone, Betasitosterol, biflavone, sterols 1. Subject and source Antidesma bunius (Linn.) Spreng. (Euphrbiaceae) ‘‘bignay† is a common plant found throughout the Philippines. The bark is poisonous as it contains an alkaloid thus, is used medicinally. The leaves are acidic and diaphoretic, and, when young, these are boiled with pot-herbs, and employed by the natives in syphilitic infections (Quisumbing, 1978). The leaves are sudorific and are employed in treating snakebite in Asia (Morton, 1987). The leaves of Antidesma bunius, commonly known as â€Å"bignay†, are traditionally used by native Filipinos to control diabetes (Lawag et al., 2012). Fresh leaves were collected from the hills of Brgy. Agustin Navarra, Ivisan, Capiz Province in January 2009. The plant was identified by Asst. Prof. Rosie A. Madulid and a voucher specimen (USTH 5357) is deposited at the UST Herbarium, Botany Laboratory, Research Center for the Natural and Applied Sciences, University of Santo Tomas (UST), Manila, Philippines. 2. Previous work Dammara-20, 24-dien-3ÃŽ ²-ol and friedelin were isolated from the stem and leaves of A. bunius (Hui and Sung, 1968). In 2008, Samappito and Butkhup identified the flavonoids catechin, Procyanidin B1 and Procyanidin B2 from the fruits and Gallic acid, quercetin, catechin and epicatechin were also detected from the fruits of A. bunius (Santiago et al., 2005). 3. Present study 3.1. Extraction and isolation Dried and ground leaves Antidesma bunius (1610 g) were extracted with 80% ethanol to give a green syrupy extract (240.0 g) which was subjected to vacuum liquid chromatography (VLC) using solvents of increasing polarity starting with hexane, hexane-dichloromethane (1:1), dichloromethane, dichloromethane -ethyl acetate (1:1), ethyl acetate, ethyl acetate-methanol (1:1), and methanol to give seven fractions. The fifth fraction (4.04 g) was further fractionated twice on silica gel packed on VLC using solvents of increasing polarity starting from hexane and ending with methanol giving five fractions each, respectively. Fraction three which was purified twice on silica gel using hexane-dichloromethane (1:1) and hexane-dichloromethane (95:5) furnished 1 (16.13 mg). Isolation of 2: the fourth fraction (12.34 g) after VLC was chromatographed on silica gel using 5-10% gradients of methanol in dichloromethane to give ten fractions. Fraction three (42.3 mg) was further purified using Sephadex LH20 using 20% gradients of methanol in DCM to give 2 (5.9 mg). (1)(2) 3.2. Identification of purified compounds The compounds were identified as Stigmast-5-en-3ÃŽ ²-ol or ÃŽ ²-sitosterol, a plant sterol, (1) (Balamurugan et al., 2012) and (Sosinska, et al., 2013) and 3,8-biapigenin (Amentoflavone), a biflavone (2) (Chari et al., 1977) and (Ryu et al., 2010) on the basis of their IR, LR-EIMS, LR-ESIMS and NMR (1H NMR, 13C NMR, 1H-1H COSY, HMBC and HSQC) spectral data and by comparison of spectra reports with the literature. 4. Chemotaxonomic significance Other Antidesma species like A. menasu (Risvi et al., 1980a), (Risvi et al., 1980b) and A. pentandrum (Chen et al., 2004), (Kikuchi, 1983) are known to contain plant sterols. A. puncticulatum is known to contain flavonoids (Nuengchamnong and Ingkaninan, 2009), while A. laciniatum was reported to contain both plant sterols and flavonoids (Tchinda et al., 2006). The isolation process that was presently preformed on the ethanolic leaf extract of A. bunius afforded compounds 1 and 2 which were coherent to the compounds that were previously isolated or reported from the other Antidesma species. Although the said compounds were reported for the very first time in A. bunius, compound 1 was also reported to be present in A. pentandrum (Chen et al., 2004) and in A. laciniatum (Tchinda et al., 2006), while compound 2 was reported to be present in A. laciniatum (Tchinda et al., 2006). This further establishes the chemotaxonomic relationship of A. bunius towards the other species of the genus Antidesma. Although plant sterols (Hui and Sung, 1968) and biflavones (Samappito and Butkhup, 2008), (Santiago et al., 2005) were previously reported in the leaf and bark extracts A. bunius, this is the first report that indicated the presence of ÃŽ ²-sitosterol (1) and Amentoflavone (2). Compounds 1 and 2 therefore add up to the list of isolated and identified compounds from the leaves of A. bunius. References Quisumbing, E., 1978. Medicinal Plants of the Philippines. Katha Publishing Inc., Quezon City, Philippines. Balamurugan, R., Stalin, A. and Ignacimuthu, S., 2012. European Journal of Medicinal Chemistry 47, 38 – 43. Chari, V. M., Ilyas, M., Wagner, H., Neszmelyi, A., Chen, F., Chen, L., Lin, Y., Lin, Y., 1977. Phytochemistry 16, 1273 – 1278. Chen, Y.C.; Cheng, M.J.; Lee, S.J.; Dixit, A.K., Ishikawa, T., Tsai, I.L.; Chen, I.S., 2004. Helvetica Chimica Acta 87 (11), 2805 – 2811. Hui, W. H.; Sung, M. L., 1968. Australian Journal of Chemistry 21(8), 2137-40. Kikuchi, H., Tensho, A., Shimizu, I., Shiokawa, H., Kuno, A., Yamada, S., Fujiwara, T., Tomita, K., 1983. Chemistry Letters (4), 603 –606. Lawag, I., Aguinaldo, A., Naheed, S., Mossihuzzaman, M., 2012. Journal of Ethnopharmacology 144(1), 217 – 219. Morton, J., 1987. Bignay. p. 210–212. Fruits of Warm Climates. Julia F. Morton, Miami, FL. Nuengchamnong, N., and Ingkaninan, K., 2010. Food Chemistry 118, 147 – 152. Samappito, S.; Butkhup, L., 2008. Pakistan Journal of Biological Sciences 11 (13), 1654 – 1661. Santiago, D.M.O., 2005. MS Thesis University of the Philippines, Los Banos. Sosinska, E., Przybylski, R., Hazendonk, P., Zhao, Y. Y., Curtis, J., 2013. Food Chemistry 139, 464 – 474. Rizvi, S. H. Shoeb, A. Kapil, R. S. Popli, S. P., 1980. Experientia 36. Birkhauser Verlag, Basel (Schweiz). Rizvi, S., Shoeb, A., Kapil, R., Popli, S., 1980. Phytochemistry 19 (11), 2409 – 10. Ryu, Y. B., Jeong, H. J., Kima, J. H., Kima, Y. M., Park, J., Kim, D., Naguyen, T.T.H., Park, S., Chang, J. S., Park, K. H., Rho, M., Lee, W. S., 2010. Bioorganic Medicinal Chemistry 18, 7940 – 7947. Tchinda, A..; Teshome, A.; Dagne, E.; Arnold, N.; Wessjohann, L., 2006. Bulletin of the Chemical Society of Ethiopia 20 (2), 325 – 328. Current Affiliations: iChemistry Department, Adamson University, Ermita, Manila, Philippines. jJinnah University for Women, Nazimabad, Karachi, Pakistan kDepartment of Chemistry, Washington State University, Pullman, WA, 99164, USA * Corresponding author. E-mail address:*[emailprotected] (I.L. Lawag)

A Good Man Is Hard To Find The Storm Essay example -- essays papers

A Good Man Is Hard To Find The Storm Of the two stories I read, one being The Storm by Kate Chopin and the other being A Good Man Is Hard To Find by Flannery O'Connor, I found that each had characters with moral dilemmas. In both, the setting played a role in these dilemmas but in different ways. In The Storm, the bad weather was the set-off to and unpredicted intimacy while in A Good Man Is Hard To Find, the setting seems to be focused around a family's vacation and their encounter with a criminal. In the following paragraphs, I will go on to explain how certain characters have moral dilemmas and how the setting helps to support my interpretations. The Storm is based around a woman by the name of Calixta who is left home alone while a threatening storm blows up suddenly. Her husband and son are stranded at a local store until the weather calms down. While she is preparing for the worst, a man visitor appears at her doorstep needing a place of shelter. This man turns out to be an old sweetheart of hers, Alcee. As the story goes on, Calixta and Alcee, unleash themse...

Itchoua Essay -- English Literature Essays

Itchoua In the story of The Three Skeleton Key written by George G. Toudouze it shows many petrifying experiences happening to the characters. Itchoua is a brave, strong Basque who visited an island just off the coast of Guiana for a couple of months. During his visit on the island, Itchoua and his friends faced many dangers and took life threatening risks. He shows many character traits of bravery through his physical description, personality and his actions toward many things. During his act of bravery, he went through many obstacles and hardships while battling the rats. He is a very heroic battler because of what he thinks, says and does in the story of Three Skeleton Key. All the risks Itchoua took while going through danger shows he’s brave by his personality, physical description and his actions. Firstly, Itchoua is a brave veteran who overcame many terrifying experiences while fighting with many vicious rats. Throughout the story, Itchoua proved that he was brave by putting his life at risk for the safety of his friends, persevered even though he was unconsicous and that he has characteristics of a leader. When the chief cried, Itchoua ran immediately not thinking at all and went to help his friend at risk. He sacrificed his life to help his friends from the dangerous rats. He cared for his friends and never only thought about himself. He did what ever he could for the safety of his friends. He used all his strength by trying to kill as many rats as possible an...

The Adverse Effects of Advertising on Women Essay -- Cause Effect Imag

The Adverse Effects of Advertising on Women Stacey was tall, blonde, tan, and slender. However beauty was not her only attribute. In addition to being voted Homecoming queen our senior year of high school, she was both a straight-A student and the President of our class. She was a strong leader who enjoyed having fun like any other girl her age. Yet in between the jokes and fun that most friends have, she was always talking about going to the gym or counting calories. Despite my constant reassurances that she was beautiful the way she was, she never felt adequate. In Stacey’s eyes nothing less than perfect would do. She believed that there was an ideal image that she had to obtain in order to be considered attractive. After trying diet after diet and joining several health programs, Stacey’s waistline finally began to get smaller; the compliments only made her want to lose more. As time went on, it was clear that her health was beginning to suffer. Her eyes had a more sunken appearance, and her once toned body looked unnaturally bony. Gradually, Stacey was starving herself. An average American will see hundreds, perhaps even thousands, of advertisements on a day-to-day basis, which attempt to manipulate impressionable minds into a new way of living. Advertisements may be good sources of information about new or revised products, but at what cost? The barrage of slender woman with perfect skin and hair emits the idea that there is such a thing as a perfect woman. The actresses, musicians, and models in these ads create a warped sense of beauty, which in turn affects women’s self-perception. Yet this goddess-like image is exactly what advertisers rely upon in order to continue their revenue. D... ...sion ads may not be real, but the affects that they have on women are. From discouragement and sadness to depression and diseases, forms of false advertising oftentimes have a negative impact on the morale of the American people, including Stacey, whose battle with anorexia continues. The saddest part of the whole scenario is that things could be different if advertisers were to put a little of their greed aside in lieu of the unique charisma of people by putting models of all shapes, sizes, and varieties in their ads. After all, who defines the normal woman anyway? Works Cited Greg Apodaca â€Å"Greg’s Digital Archive† Greg Apodaca’s Website. September 22, 2003. National Institute of Mental Health â€Å"Depression† Publication No. 02-3561 (2000).

Government-operated Gambling

Over the past few years, government operated gambling has grown into a massive business, there has been much controversy around the topic of weather or not Gambling should be regulated. In this essay I will explain my point of view on this topic and give examples that support my ideas. So, what should the state’s policy towards gambling? I believe that the state should not regulate gambling because of three main reasons. My first reason is people’s rights and freedoms.Second, Gambling has grown into a major industry over the pas few years; the centre for addiction and mental health stated in their Gambling Policy framework in 2011 â€Å"Government-operated gambling has steadily expanded in Ontario in the past two decades, revenues reaching $4. 7 billion in 2009. † (2). This shows that Gambling has grown to become a major industry in today’s economy and by doing so it has helped society in several different aspects, the growth of the gambling industry has l ead to an increase in revenue for the government, thus resulting in more social benefits towards the public.Finally, The gambling industry has lead to many job opportunities in north America, offering a beacon of hope to those in need of jobs during a recession. In modern society, freedom is not only supported but also cherished, people should be given the freedom to live their lives as they please, weather they choose to live their lives in a healthy way or not that is up to them. However, they must be given the right to live as they please. In the United States, groups such as the KKK are protected under the first amendment, which protects their freedom of speech, no matter how ludicrous it may be, they have the right to say as they please.The same should be applied to life. People should have the choice to live their lives as they please without being watched over by the government. Since gambling does require participants to be of legal age, we know that the people gambling are adults. These grown ups should be able to have control over their own lives, its their responsibility to understand the chances they are taking when gambling. Some may argue that certain people can’t control their gambling problems and have gotten too addicted to gambling and that casinos take advantage of these people.These claims are supported by some statistics given in the centre for addiction and mental health, which states, â€Å"it is estimated that between 30% and 40% of Ontario’s gambling revenues come from the 3% of the population with gambling problems† (2). This statistic shows that the gambling industry does heavily depend of the people addicted to the game. I would respond by expressing two points. First, the people with gambling problems of which they cannot control are a minority, in Jonathan Wolff’s â€Å"Ethics and public policy A Philosophical inquiry†, the author states that â€Å"between 0. and 0. 8 of the UK adult population could be classified as problem gambles† (59). Furthermore, in the centre for addiction and mental health’s Gambling Policy framework in 2011 that â€Å"just over 3% of the province’s population experiences moderate to severe gambling problems. †(57). These numbers do not justify having to discipline an entire industry that would affect hundreds of thousands of people that work in it and making their living off jobs in that industry.Second, increasing government regulations on casinos and lotteries will not stop these problem gamblers from gambling. Jonathan Wolff states â€Å"in the late 1950s there were towns about 25 percent of the adult population gambled illegally on a regular basis. †(55). Taking this point into perspective, it could be inferred that if the government increases the regulations on legal casinos and lotteries that would make it harder for people with an addiction to gamble, these people will find other ways to feed their addictio n.This is a severe problem because when these people begin to gamble illegally they will put their money into other illegal activities, which could include drugs, weapons or violence. In fact, many large gangs could use this opportunity to fund their illegal activities, which would lead to more trouble in society; another point to be made towards this issue would be that of money, not only would these gamblers be putting their lives at risk when gambling illegally and dealing with gangs, but they could also be keeping this money out of the government’s hand which could go government programs to help the less fortunate.This brings me to my next point and that is that gambling has become a major source of revenue for the government. Government regulated gambling has grown into a massive industry which generates a significant amount of revenue each year of which most ends up in the government as funding for many different organizations. in the paper named â€Å"Gambling: Its Pl easure and costs† by Lorne Tepperman it states that â€Å"The industry group’s report †¦ says 57 per cent of gambling revenue – $8. 7 billion- supported government services and charities. (9). Tepperman also states that gambling is the â€Å"most financially significant† (9) segment in entertainment and that it contributes â€Å"$15. 3 billion a year to the economy, according to the Canadian Gaming Association. † (9). Ronald Pavalko also states in his paper titled â€Å"gambling and public policy† â€Å"State revenues from casino taxes totaled nearly $3. 5 billion. † (336). The reality is that today, we are in a recession we can’t afford to decrease that revenue by implementing harsh restrictions on gambling.It is argued that even though gambling is a major source of revenue for the government, it is also a source of misery for people with gambling addictions. The centre for Addiction and Mental health states that â€Å"F or these individuals, a range of harms may occur, resulting in heavy social, economic, and health costs such as crime, dysfunctional relationships, and bankruptcy. † (2). However, the solution to this problem is not adding restrictions to gambling but is actually using the money made from gambling towards a better cause.As I have previously stated, people addicted to gambling will not be cured from their addiction by regulating legal gambling because they will find other means to feed their addiction. I believe that the best solution to these people’s gambling problem would be using the revenue that they generate for the government in taxes could be used to create social programs for people with serious addictions to gambling that would help them quit.I believe this solution would be ideal because the minority of people with gambling addictions will be treated in a proper healthy way in order to get over their addiction, the left over revenue could still be used in othe r social programs and finally, the money and profit that the casinos and lotteries generate will still flow which would result in more jobs, another source of income to the economy and would prevent people from getting fired from their jobs if harsh restrictions were to be applied to gambling agencies.My final argument for this essay is that of employment. As previously stated, gambling generates a huge amount of revenue for the government, Gambling is a growing industry and with its growth it creates several opportunities for jobs for people in need. Gambling generates many jobs that help the economy grow in this time of need. Gambling generates jobs of all sorts, from the engineers and architects that build and design the casinos, to the people who sell lottery tickets, to those who actually work in casinos.All of these people generate their income because of the gambling industry. Tepperman states that in Canada gambling accounts for â€Å"267,000 full time jobs. † (6). Pa valko also states in his paper that in only eleven states a total of 370,207 people are employed in casinos, In a country with a current unemployment rate of 8%, the Gambling industry should be seen as a source for solutions to a much more serious problem than an addiction to gambling. Expanding the gambling industry will in return create more job opportunities and help decrease the unemployment rate dramatically.However, if the government begins to set harsher policies towards gambling and casinos are required to cut costs, the unemployment rate might increase which would create even more social issue, which could result in protests and riots from the workers who have lost their jobs due to the harsh policy towards gambling. Some might argue that Gambling still creates harm towards many people and even though it can create jobs it can also result in many people losing their jobs. I would respond by quoting Lorne Tepperman â€Å"A majority of adults gamble responsible; only a small minority of the population experiences gambling related harm. (1). I believe that gambling will create more jobs that it will end and that that is just a minor side effect that could be easily cured by the revenue that gambling will generate for the government, this money could be put back into society and produce new projects that create new job opportunities and these jobs could be offered to those who had lost their previous jobs. In conclusion I would say that I do not believe that the government should regulate gambling because of the reasons that I have stated earlier in this essay.First, Gambling is a choice and freedom. It a civil right and the government should not be able to decide weather or not you are allowed to gamble or how much you are allowed to gamble. Second, Gambling has grown into a major industry and has become a major source of revenue to the government. Gambling has helped fund many government programs used to help the less fortunate, even though gambling do es create certain people who are addicted to it, they are nowhere near as many as the people whom gambling helps.In this situation the pros drastically outweigh the cons and as previously stated, the revenue generated from gambling could go towards social programs made to help people with gambling addictions, that way these people will eventually cure themselves of their addiction and the hundreds of thousands of people whom depend on gambling a source of income would not be affected, which is what I believe is a win-win situation. This brings me to my final argument, employment.The gambling industry has created hundreds of thousands of job opportunities to many of those who need it, especially in a recession where millions struggle to find an income support for them and their families. I would say that the government should encourage gambling businesses to grow. However, as Christiane Pouline states in his paper titled â€Å"Gambling† that â€Å"Decisions on policy pertaini ng to gambling need to be based on a full accounting of the health, economic and social benefits and costs of gambling. (1208). Which is why the policy towards gambling should be set to help both the gambler and the Casinos. That policy should state that a majority of the profit that is generated from Casinos should go towards social programs that will benefit society; these social programs should include programs made to help gambling addicts with their problems. James Doughney perfectly sums up this policy in his book titled â€Å"The poker machine state†.Doughney says, â€Å"Try to do good; but even when you cannot at least do not knowingly cause harm. † (1). Over the past several years, gambling has grown into the largest sector of the entertainment industry, creating the most amount of revenue to the government. Our society should be scared of this phenomenon and try to regulate it, we should actually take advantage of it and use it to help make the most the most of this opportunity by using the money made from gambling to improve our lives and the lives of those around us.